Human gait recognition using topological information

This paper shows an image/video application using topological invariants in human gait recognition. The 3D volume of a gait cycle is built stacking silhouettes extracted using a background substraction approach. Ideally, the border cell complex is obtained from the 3D volume with one connected component and one cavity. Then, it is necessary to apply a topological enrichment strategy in order to obtain a robust and discriminative representation for person recognition. Using a sliding cutter plane normal to some direction of view it is possible to divide the border cell complex in different parts. The incremental algorithm is used to compute the homology on each part. A vectorial representation is built ordering the number of connected components and tunnels obtained for each cut. In order to evaluate the robustness of this representation the silhouettes were diminished to a quarter of the original size. At the same time, this is considered a simulation of a human gait captured at long distance. Even, under these difficult conditions it was possible to get a 74% of correct classification rates on CASIA-B database

Persistent-homology-based gait recognition

Gait recognition is an important biometric technique for video surveillance tasks, due to the advantage of using it at distance. In this paper, we present a persistent homology-based method to extract topological features (the so-called topological gait signature) from the the body silhouettes of a gait sequence. It has been used before in sev- eral conference papers of the same authors for human identi cation, gender classi cation, carried object detection and monitoring human activities at distance. The novelty of this paper is the study of the sta- bility of the topological gait signature under small perturbations and the number of gait cycles contained in a gait sequence. In other words, we show that the topological gait signature is robust to the presence of noise in the body silhouettes and to the number of gait cycles con- tained in a given gait sequence. We also show that computing our topological gait signature of only the lowest fourth part of the body silhouette, we avoid the upper body movements that are unrelated to the natural dynamic of the gait, caused for example by carrying a bag or wearing a coat.Ministerio de Economía y Competitividad MTM2015-67072-

An application for gait recognition using persistent homology

This Demo presents an application for gait recognition using persistent homology. Using a background subtraction approach, a silhouette sequence is obtained from a camera in a controlled environment. A border simplicial complex is built stacking silhouettes aligned by their gravity center. A multifiltration is applied on the border simplicial complex which captures relations among the parts of the human body when walking. Finally, the topological gait signature is extracted from the persistence barcode according to each filtration. The measure cosine is used to give a similarity value between topological signatures. The input of this Demo are videos with resolution 320x240 to 25f ps. The videos in CASIA-B database are used to prove the efficacy and efficiency. A computer with 2Gb of RAM memory and a DualCore processor was used to test the implementation of the proposed algorithm. In this Demo all related tasks have been programmed by the authors in the C++ programming language. OpenCV library has been used for the image processing part

Algorithm to Compute a Minimal Length Basis of Representative Cocycles of Cohomology Generators

An algorithm to compute a minimal length basis of representative cocycles of cohomology generators for 2D images is proposed. We based the computations on combinatorial pyramids foreseeing its future extension to 3D objects. In our research we are looking for a more refined topological description of deformable 2D and 3D shapes, than they are the often used Betti numbers. We define contractions on the object edges toward the inner of the object until the boundaries touch each other, building an irregular pyramid with this purpose. We show the possible use of the algorithm seeking the minimal cocycles that connect the convex deficiencies on a human silhouette. We used minimality in the number of cocycle edges in the basis, which is a robust description to rotations and noise

Persistent homology-based gait recognition robust to upper body variations

Gait recognition is nowadays an important biometric technique for video surveillance tasks, due to the advantage of using it at distance. However, when the upper body movements are unrelated to the natural dynamic of the gait, caused for example by carrying a bag or wearing a coat, the reported results show low accuracy. With the goal of solving this problem, we apply persistent homology to extract topological features from the lowest fourth part of the body silhouettes. To obtain the features, we modify our previous algorithm for gait recognition, to improve its efficacy and robustness to variations in the amount of simplices of the gait complex. We evaluate our approach using the CASIA-B dataset, obtaining a considerable accuracy improvement of 93:8%, achieving at the same time invariance to upper body movements unrelated with the dynamic of the gait.Ministerio de Economía y Competitividad MTM2015-67072-

Tumor microenvironment gene expression profiles associated to complete pathological response and disease progression in resectable NSCLC patients treated with neoadjuvant chemoimmunotherapy

Background Neoadjuvant chemoimmunotherapy for non-small cell lung cancer (NSCLC) has improved pathological responses and survival rates compared with chemotherapy alone, leading to Food and Drug Administration (FDA) approval of nivolumab plus chemotherapy for resectable stage IB-IIIA NSCLC (AJCC 7th edition) without ALK or EGFR alterations. Unfortunately, a considerable percentage of tumors do not completely respond to therapy, which has been associated with early disease progression. So far, it is impossible to predict these events due to lack of knowledge. In this study, we characterized the gene expression profile of tumor samples to identify new biomarkers and mechanisms behind tumor responses to neoadjuvant chemoimmunotherapy and disease recurrence after surgery. Methods Tumor bulk RNA sequencing was performed in 16 pretreatment and 36 post-treatment tissue samples from 41 patients with resectable stage IIIA NSCLC treated with neoadjuvant chemoimmunotherapy from NADIM trial. A panel targeting 395 genes related to immunological processes was used. Tumors were classified as complete pathological response (CPR) and non-CPR, based on the total absence of viable tumor cells in tumor bed and lymph nodes tested at surgery. Differential-expressed genes between groups and pathway enrichment analysis were assessed using DESeq2 and gene set enrichment analysis. CIBERSORTx was used to estimate the proportions of immune cell subtypes. Results CPR tumors had a stronger pre-established immune infiltrate at baseline than non-CPR, characterized by higher levels of IFNG, GZMB, NKG7, and M1 macrophages, all with a significant area under the receiver operating characteristic curve (ROC) >0.9 for CPR prediction. A greater effect of neoadjuvant therapy was also seen in CPR tumors with a reduction of tumor markers and IFN gamma signaling after treatment. Additionally, the higher expression of several genes, including AKT1, BST2, OAS3, or CD8B; or higher dendritic cells and neutrophils proportions in post-treatment non-CPR samples, were associated with relapse after surgery. Also, high pretreatment PD-L1 and tumor mutational burden levels influenced the post-treatment immune landscape with the downregulation of proliferation markers and type I interferon signaling molecules in surgery samples. Conclusions Our results reinforce the differences between CPR and non-CPR responses, describing possible response and relapse immune mechanisms, opening the possibility of therapy personalization of immunotherapy-based regimens in the neoadjuvant setting of NSCLC

Determination of essential biomarkers in lung cancer : a real-world data study in Spain with demographic, clinical, epidemiological and pathological characteristics

Background The survival of patients with lung cancer has substantially increased in the last decade by about 15%. This increase is, basically, due to targeted therapies available for advanced stages and the emergence of immunotherapy itself. This work aims to study the situation of biomarker testing in Spain. Patients and methods The Thoracic Tumours Registry (TTR) is an observational, prospective, registry-based study that included patients diagnosed with lung cancer and other thoracic tumours, from September 2016 to 2020. This TTR study was sponsored by the Spanish Lung Cancer Group (GECP) Foundation, an independent, scientific, multidisciplinary oncology society that coordinates more than 550 experts and 182 hospitals across the Spanish territory. Results Nine thousand two hundred thirty-nine patients diagnosed with stage IV non-small cell lung cancer (NSCLC) between 2106 and 2020 were analysed. 7,467 (80.8%) were non-squamous and 1,772 (19.2%) were squamous. Tumour marker testing was performed in 85.0% of patients with non-squamous tumours vs 56.3% in those with squamous tumours (p-value < 0.001). The global testing of EGFR, ALK, and ROS1 was 78.9, 64.7, 35.6% respectively, in non-squamous histology. PDL1 was determined globally in the same period (46.9%), although if we focus on the last 3 years it exceeds 85%. There has been a significant increase in the last few years of all determinations and there are even close to 10% of molecular determinations that do not yet have targeted drug approval but will have it in the near future. 4,115 cases had a positive result (44.5%) for either EGFR, ALK, KRAS, BRAF, ROS1, or high PDL1. Conclusions Despite the lack of a national project and standard protocol in Spain that regulates the determination of biomarkers, the situation is similar to other European countries. Given the growing number of different determinations and their high positivity, national strategies are urgently needed to implement next-generation sequencing (NGS) in an integrated and cost-effective way in lung cancer

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P &lt; 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Topological signature for periodic motion recognition

In this paper, we present an algorithm that computes the topological signature for a given periodic motion sequence. Such signature consists of a vector obtained by persistent homology which captures the topological and geometric changes of the object that models the motion. Two topological signatures are compared simply by the angle between the corresponding vectors. With respect to gait recognition, we have tested our method using only the lowest fourth part of the body’s silhouette. In this way, the impact of variations in the upper part of the body, which are very frequent in real scenarios, decreases considerably. We have also tested our method using other periodic motions such as running or jumping. Finally, we formally prove that our method is robust to small perturbations in the input data and does not depend on the number of periods contained in the periodic motion sequence.Junta de Andalucía FQM-369Ministerio de Economía y Competitividad MTM2015-67072-